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1. Structural and functional insights into the interaction between the bacteriophage T4 DNA processing proteins gp32 and Dda
2. What is the real value of omics data? Enhancing research outcomes and securing long-term data excellence
3. Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA
4. SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency
5. Mycobacterium smegmatis NucS-promoted DNA mismatch repair involves limited resection by a 5′-3′ exonuclease and is independent of homologous recombination and NHEJ
6. Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1
7. Core enhancers of the 3′RR optimize IgH nuclear position and loop conformation for successful oriented class switch recombination
8. Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa
9. Localization and discrimination of GG mismatch in duplex DNA by synthetic ligand-enhanced protein nanopore analysis
10. Massively parallel binding assay (MPBA) reveals limited transcription factor binding cooperativity, challenging models of specificity
11. Correction to ‘Accelerated discovery and miniaturization of novel single-stranded cytidine deaminases’
12. Probing the mechanism of nick searching by LIG1 at the single-molecule level
13. Pipolins are bimodular platforms that maintain a reservoir of defense systems exchangeable with various bacterial genetic mobile elements
14. Correction to ‘DORQ-seq: high-throughput quantification of femtomol tRNA pools by combination of cDNA hybridization and Deep sequencing’
15. Dual decoding of cell types and gene expression in spatial transcriptomics with PANDA
16. Re-appraising the evidence for the source, regulation and function of p53-family isoforms
17. Chromosomal integrons are genetically and functionally isolated units of genomes
18. Visualization of Type IV-A1 CRISPR-mediated repression of gene expression and plasmid replication
19. Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4
20. Revisiting the y-ome of Escherichia coli
21. Pathological R-loops in bacteria from engineered expression of endogenous antisense RNAs whose synthesis is ordinarily terminated by Rho
22. Self-assembly and condensation of intermolecular poly(UG) RNA quadruplexes
23. PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators
24. Correction to ‘CRISPR perfect adaptation for robust control of cellular immune and apoptotic responses’
25. Establishment of closed 35S ribosomal RNA gene chromatin in stationary Saccharomyces cerevisiae cells
26. Altered dNTP pools accelerate tumor formation in mice
27. Selective degradation of phage RNAs by the Csm6 ribonuclease provides robust type III CRISPR immunity in Streptococcus thermophilus
28. Structural mechanisms of SLF1 interactions with Histone H4 and RAD18 at the stalled replication fork
29. Nuclease-induced stepwise photodropping (NISP) to precisely investigate single-stranded DNA degradation behaviors of exonucleases and endonucleases
30. Protein–RNA interactions mediated by silvestrol—insight into a unique molecular clamp
31. N2-Alkyl-dG lesions elicit R-loop accumulation in the genome
32. The TRIM-NHL RNA-binding protein Brain Tumor coordinately regulates expression of the glycolytic pathway and vacuolar ATPase complex
33. Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
34. Haplotype-resolved de novo assembly revealed unique characteristics of alternative lengthening of telomeres in mouse embryonic stem cells
35. The Swi5–Sfr1 complex regulates Dmc1- and Rad51-driven DNA strand exchange proceeding through two distinct three-stranded intermediates by different mechanisms
36. The interplay between peptides and RNA is critical for protoribosome compartmentalization and stability
37. Human hnRNPA1 reorganizes telomere-bound replication protein A
38. Phylogenomic instructed target analysis reveals ELAV complex binding to multiple optimally spaced U-rich motifs
39. 3,N4-Etheno-5-methylcytosine blocks TET1-3 oxidation but is repaired by ALKBH2, 3 and FTO
40. Evolving Escherichia coli to use a tRNA with a non-canonical fold as an adaptor of the genetic code
41. Switch-like phosphorylation of WRN integrates end-resection with RAD51 metabolism at collapsed replication forks
42. Disparate requirements for RAD54L in replication fork reversal
43. p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis
44. DciA secures bidirectional replication initiation in Vibrio cholerae
45. Revisiting the model for coactivator recruitment: Med15 can select its target sites independent of promoter-bound transcription factors
46. TIRR regulates mRNA export and association with P-bodies in response to DNA damage
47. Genome editing outcomes reveal mycobacterial NucS participates in a short-patch repair of DNA mismatches
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近期历史最近 100 条记录

2024-11-11 Structural and functional insights into the interaction between the bacteriophage T4 DNA processing proteins gp32 and Dda
2024-11-11 What is the real value of omics data? Enhancing research outcomes and securing long-term data excellence
2024-11-11 Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA
2024-11-11 SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency
2024-11-11 Mycobacterium smegmatis NucS-promoted DNA mismatch repair involves limited resection by a 5′-3′ exonuclease and is independent of homologous recombination and NHEJ
2024-11-11 Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1
2024-11-11 Core enhancers of the 3′RR optimize IgH nuclear position and loop conformation for successful oriented class switch recombination
2024-11-11 Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa
2024-11-11 Localization and discrimination of GG mismatch in duplex DNA by synthetic ligand-enhanced protein nanopore analysis
2024-11-11 Massively parallel binding assay (MPBA) reveals limited transcription factor binding cooperativity, challenging models of specificity
2024-11-11 Correction to ‘Accelerated discovery and miniaturization of novel single-stranded cytidine deaminases’
2024-11-11 Probing the mechanism of nick searching by LIG1 at the single-molecule level
2024-11-11 Pipolins are bimodular platforms that maintain a reservoir of defense systems exchangeable with various bacterial genetic mobile elements
2024-11-11 Correction to ‘DORQ-seq: high-throughput quantification of femtomol tRNA pools by combination of cDNA hybridization and Deep sequencing’
2024-11-11 Dual decoding of cell types and gene expression in spatial transcriptomics with PANDA
2024-11-11 Re-appraising the evidence for the source, regulation and function of p53-family isoforms
2024-11-11 Chromosomal integrons are genetically and functionally isolated units of genomes
2024-11-11 Visualization of Type IV-A1 CRISPR-mediated repression of gene expression and plasmid replication
2024-11-11 Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4
2024-11-11 Revisiting the y-ome of Escherichia coli
2024-11-11 Pathological R-loops in bacteria from engineered expression of endogenous antisense RNAs whose synthesis is ordinarily terminated by Rho
2024-11-11 Self-assembly and condensation of intermolecular poly(UG) RNA quadruplexes
2024-11-11 PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators
2024-11-11 Correction to ‘CRISPR perfect adaptation for robust control of cellular immune and apoptotic responses’
2024-11-11 Establishment of closed 35S ribosomal RNA gene chromatin in stationary Saccharomyces cerevisiae cells
2024-11-11 Altered dNTP pools accelerate tumor formation in mice
2024-11-11 Selective degradation of phage RNAs by the Csm6 ribonuclease provides robust type III CRISPR immunity in Streptococcus thermophilus
2024-11-11 Structural mechanisms of SLF1 interactions with Histone H4 and RAD18 at the stalled replication fork
2024-11-11 Nuclease-induced stepwise photodropping (NISP) to precisely investigate single-stranded DNA degradation behaviors of exonucleases and endonucleases
2024-11-11 Protein–RNA interactions mediated by silvestrol—insight into a unique molecular clamp
2024-11-11 N2-Alkyl-dG lesions elicit R-loop accumulation in the genome
2024-11-11 The TRIM-NHL RNA-binding protein Brain Tumor coordinately regulates expression of the glycolytic pathway and vacuolar ATPase complex
2024-11-11 Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
2024-11-11 Haplotype-resolved de novo assembly revealed unique characteristics of alternative lengthening of telomeres in mouse embryonic stem cells
2024-11-11 The Swi5–Sfr1 complex regulates Dmc1- and Rad51-driven DNA strand exchange proceeding through two distinct three-stranded intermediates by different mechanisms
2024-11-11 The interplay between peptides and RNA is critical for protoribosome compartmentalization and stability
2024-11-11 Human hnRNPA1 reorganizes telomere-bound replication protein A
2024-11-11 Phylogenomic instructed target analysis reveals ELAV complex binding to multiple optimally spaced U-rich motifs
2024-11-11 3,N4-Etheno-5-methylcytosine blocks TET1-3 oxidation but is repaired by ALKBH2, 3 and FTO
2024-11-11 Evolving Escherichia coli to use a tRNA with a non-canonical fold as an adaptor of the genetic code
2024-11-11 Switch-like phosphorylation of WRN integrates end-resection with RAD51 metabolism at collapsed replication forks
2024-11-11 Disparate requirements for RAD54L in replication fork reversal
2024-11-11 p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis
2024-11-11 DciA secures bidirectional replication initiation in Vibrio cholerae
2024-11-11 Revisiting the model for coactivator recruitment: Med15 can select its target sites independent of promoter-bound transcription factors
2024-11-11 TIRR regulates mRNA export and association with P-bodies in response to DNA damage
2024-11-11 Genome editing outcomes reveal mycobacterial NucS participates in a short-patch repair of DNA mismatches
2024-10-28 Closing in on human methylation—the versatile family of seven-β-strand (METTL) methyltransferases
2024-10-28 Enhanced Golden Gate Assembly: evaluating overhang strength for improved ligation efficiency
2024-10-28 Combining Nanopore direct RNA sequencing with genetics and mass spectrometry for analysis of T-loop base modifications across 42 yeast tRNA isoacceptors
2024-10-28 Stochastic nature and physiological implications of 5′-NAD RNA cap in bacteria
2024-10-28 DNA-binding proteins from MBD through ZF to BEN: recognition of cytosine methylation status by one arginine with two conformations
2024-10-28 Testis-specific H2B.W1 disrupts nucleosome integrity by reducing DNA–histone interactions
2024-10-28 A transcription-independent role for HIF-1α in modulating microprocessor assembly
2024-10-28 Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells
2024-10-28 FRAME: flap endonuclease 1-engineered PAM module for precise and sensitive modulation of CRISPR/Cas12a trans-cleavage activity
2024-10-28 Structural and mechanistic insights into a mesophilic prokaryotic Argonaute
2024-10-28 The transition state for coupled folding and binding of a disordered DNA binding domain resembles the unbound state
2024-10-28 Kinetic mechanism and determinants of EF-P recruitment to translating ribosomes
2024-10-28 Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing
2024-10-28 Phage defence loci of Streptococcus thermophilus—tip of the anti-phage iceberg?
2024-10-28 High-throughput single telomere analysis using DNA microarray and fluorescent in situ hybridization
2024-10-28 Polyubiquitinated PCNA triggers SLX4-mediated break-induced replication in alternative lengthening of telomeres (ALT) cancer cells
2024-10-28 G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism
2024-10-28 4CAC: 4-class classifier of metagenome contigs using machine learning and assembly graphs
2024-10-28 Transcription start site scanning requires the fungi-specific hydrophobic loop of Tfb3
2024-10-28 A deep learning-based method enables the automatic and accurate assembly of chromosome-level genomes
2024-10-28 Mei5–Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA
2024-10-28 Advancing microRNA target site prediction with transformer and base-pairing patterns
2024-10-28 DNA breathing integration with deep learning foundational model advances genome-wide binding prediction of human transcription factors
2024-10-28 IRescue: uncertainty-aware quantification of transposable elements expression at single cell level
2024-10-28 Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA
2024-10-28 CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver
2024-10-28 DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5
2024-10-28 MBNL splicing factors regulate the microtranscriptome of skeletal muscles
2024-10-28 A single rare σ70 variant establishes a unique gene expression pattern in the E. coli pathobiont LF82
2024-10-28 Nucleotide excision repair of aflatoxin-induced DNA damage within the 3D human genome organization
2024-10-28 LAP2alpha facilitates myogenic gene expression by preventing nucleoplasmic lamin A/C from spreading to active chromatin regions
2024-10-28 Elucidating microRNA-34a organisation within human Argonaute-2 by dynamic nuclear polarisation-enhanced magic angle spinning NMR
2024-10-28 DNA methylation by CcrM contributes to genome maintenance in the Agrobacterium tumefaciens plant pathogen
2024-10-28 Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency
2024-10-28 Eukaryotic initiation factor 4B is a multi-functional RNA binding protein that regulates histone mRNAs
2024-10-28 The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site
2024-10-28 PARP1-TRIM44-MRN loop dictates the response to PARP inhibitors
2024-10-28 ADAR3 modulates neuronal differentiation and regulates mRNA stability and translation
2024-10-28 Elucidation of the molecular mechanism of the breakage-fusion-bridge (BFB) cycle using a CRISPR-dCas9 cellular model
2024-10-28 Synergistic action of human RNaseH2 and the RNA helicase-nuclease DDX3X in processing R-loops
2024-10-28 Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome
2024-10-28 A plant-specific clade of serine/arginine-rich proteins regulates RNA splicing homeostasis and thermotolerance in tomato
2024-10-28 RNA-directed peptide synthesis across a nicked loop
2024-10-28 A CRISPR-dCas13 RNA-editing tool to study alternative splicing
2024-10-28 RNA helicase D1PAS1 resolves R-loops and forms a complex for mouse pachytene piRNA biogenesis required for male fertility
2024-10-28 Sarbecovirus programmed ribosome frameshift RNA element folding studied by NMR spectroscopy and comparative analyses
2024-10-28 KREH2 helicase represses ND7 mRNA editing in procyclic-stage Trypanosoma brucei by opposite modulation of canonical and ‘moonlighting’ gRNA utilization creating a proposed mRNA structure
2024-10-28 Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation
2024-10-14 Correction to ‘Expanded MutaT7 toolkit efficiently and simultaneously accesses all possible transition mutations in bacteria’
2024-10-14 Correction to ‘Advancing quantitative PCR with color cycle multiplex amplification’
2024-10-14 Crystal structure and nucleic acid binding mode of CPV NSP9: implications for viroplasm in Reovirales
2024-10-14 How to scan naked DNA using promiscuous recognition and no clamping: a model for pioneer transcription factors
2024-10-14 Learning to quantify uncertainty in off-target activity for CRISPR guide RNAs

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