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近期历史最近 100 条记录

2024-11-21 Vagal stimulation ameliorates murine colitis by regulating SUMOylation | Science Translational Medicine
2024-11-21 NIT2 dampens BRD1 phase separation and restrains oxidative phosphorylation to enhance chemosensitivity in gastric cancer | Science Translational Medicine
2024-11-21 Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells | Science Translational Medicine
2024-11-21 Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration | Science Translational Medicine
2024-11-21 Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis | Science Translational Medicine
2024-11-21 Delayed low-dose oral administration of 4′-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease | Science Translational Medicine
2024-11-21 Erratum for the Research Article “An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease” by A. Ghosh et al. | Science Translational Medicine
2024-11-21 Erratum for the Research Article “Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice” by S. Gaikwad et al. | Science Translational Medicine
2024-11-14 Sex differences and immune correlates of Long Covid development, symptom persistence, and resolution | Science Translational Medicine
2024-11-14 Translating insights into therapies for Long Covid | Science Translational Medicine
2024-11-14 Animal models of Long Covid: A hit-and-run disease | Science Translational Medicine
2024-11-14 Consequences beyond acute SARS-CoV-2 infection in children | Science Translational Medicine
2024-11-14 Infection-associated chronic conditions: Why Long Covid is our best chance to untangle Osler’s web | Science Translational Medicine
2024-11-14 Sex differences in postacute infection syndromes | Science Translational Medicine
2024-11-14 Symptoms after Lyme disease: What’s past is prologue | Science Translational Medicine
2024-11-14 Initiating Long Covid RECOVERy | Science Translational Medicine
2024-11-07 Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population | Science Translational Medicine
2024-11-07 Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice | Science Translational Medicine
2024-11-07 The R1441C-Lrrk2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner in mice | Science Translational Medicine
2024-11-07 Monoclonal antibodies against the spike protein alter the endogenous humoral response to SARS-CoV-2 vaccination and infection | Science Translational Medicine
2024-11-07 Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients | Science Translational Medicine
2024-11-07 Transient anti-interferon autoantibodies in the airways are associated with recovery from COVID-19 | Science Translational Medicine
2024-10-31 Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains | Science Translational Medicine
2024-10-31 Inhibition of an Alzheimer’s disease–associated form of necroptosis rescues neuronal death in mouse models | Science Translational Medicine
2024-10-31 Bayesian modeling for analyzing heterogeneous response in preclinical mouse tumor models | Science Translational Medicine
2024-10-31 A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy | Science Translational Medicine
2024-10-31 Protumoral lipid droplet–loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted | Science Translational Medicine
2024-10-31 Engineering CAR-T therapies for autoimmune disease and beyond | Science Translational Medicine
2024-10-24 Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy | Science Translational Medicine
2024-10-24 Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy | Science Translational Medicine
2024-10-24 Characterization of clonal dynamics using duplex sequencing in donor-recipient pairs decades after hematopoietic cell transplantation | Science Translational Medicine
2024-10-24 Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa | Science Translational Medicine
2024-10-24 SARS-CoV-2 XBB.1.5 mRNA booster vaccination elicits limited mucosal immunity | Science Translational Medicine
2024-10-24 From blood to mucosa | Science Translational Medicine
2024-10-17 Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons | Science Translational Medicine
2024-10-17 Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis | Science Translational Medicine
2024-10-17 Intraoperative evaluation of tumor margins using a TROP2 near-infrared imaging probe to enable human breast-conserving surgery | Science Translational Medicine
2024-10-17 High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease | Science Translational Medicine
2024-10-17 Human OX40L–CAR-Tregs target activated antigen-presenting cells and control T cell alloreactivity | Science Translational Medicine
2024-10-10 A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis | Science Translational Medicine
2024-10-10 Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes | Science Translational Medicine
2024-10-10 Sleep-sensitive dopamine receptor expression in male mice underlies attention deficits after a critical period of early adversity | Science Translational Medicine
2024-10-10 A multispecific antibody against SARS-CoV-2 prevents immune escape in vitro and confers prophylactic protection in vivo | Science Translational Medicine
2024-10-10 An altered natural killer cell immunophenotype characterizes clinically severe pediatric RSV infection | Science Translational Medicine
2024-10-03 Glucocorticoids induce a maladaptive epithelial stress response to aggravate acute kidney injury | Science Translational Medicine
2024-10-03 A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice | Science Translational Medicine
2024-10-03 A microbiome-directed therapeutic food for children recovering from severe acute malnutrition | Science Translational Medicine
2024-10-03 LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson’s disease | Science Translational Medicine
2024-10-03 Dynamic structural remodeling of LINC01956 enhances temozolomide resistance in MGMT-methylated glioblastoma | Science Translational Medicine
2024-09-26 Neutrophil extracellular traps protect the kidney from ascending infection and are required for a positive leukocyte dipstick test | Science Translational Medicine
2024-09-26 B cells drive neuropathic pain–related behaviors in mice through IgG–Fc gamma receptor signaling | Science Translational Medicine
2024-09-26 Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models | Science Translational Medicine
2024-09-26 Reduction of prolonged excitatory neuron swelling after spinal cord injury improves locomotor recovery in mice | Science Translational Medicine
2024-09-26 Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose | Science Translational Medicine
2024-09-26 Clinical, mechanistic, and therapeutic landscape of cutaneous fibrosis | Science Translational Medicine
2024-09-19 Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis | Science Translational Medicine
2024-09-19 Perfusion imaging metrics after acute traumatic spinal cord injury are associated with injury severity in rats and humans | Science Translational Medicine
2024-09-19 ARGX-119 is an agonist antibody for human MuSK that reverses disease relapse in a mouse model of congenital myasthenic syndrome | Science Translational Medicine
2024-09-19 Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade | Science Translational Medicine
2024-09-19 Preschool-age children maintain a distinct memory CD4+ T cell and memory B cell response after SARS-CoV-2 infection | Science Translational Medicine
2024-09-19 A deep intronic splice–altering AIRE variant causes APECED syndrome through antisense oligonucleotide-targetable pseudoexon inclusion | Science Translational Medicine
2024-09-12 Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging | Science Translational Medicine
2024-09-12 A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories | Science Translational Medicine
2024-09-12 Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models | Science Translational Medicine
2024-09-12 HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis | Science Translational Medicine
2024-09-12 BATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML | Science Translational Medicine
2024-09-12 Erratum for the Research Article “Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70” by B. Brook et al. | Science Translational Medicine
2024-09-05 Adaptive cognitive control circuit changes associated with problem-solving ability and depression symptom outcomes over 24 months | Science Translational Medicine
2024-09-05 PTPRT loss enhances anti–PD-1 therapy efficacy by regulation of STING pathway in non–small cell lung cancer | Science Translational Medicine
2024-09-05 A skin-interfaced microfluidic platform supports dynamic sweat biochemical analysis during human exercise | Science Translational Medicine
2024-09-05 Inhibition of CCL7 improves endothelial dysfunction and vasculopathy in mouse models of diabetes mellitus | Science Translational Medicine
2024-09-05 Precision adjuvants for pediatric vaccines | Science Translational Medicine
2024-08-29 Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer | Science Translational Medicine
2024-08-29 Activation and antitumor immunity of CD8+ T cells are supported by the glucose transporter GLUT10 and disrupted by lactic acid | Science Translational Medicine
2024-08-29 An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction | Science Translational Medicine
2024-08-29 Inhibiting endothelial Rhoj blocks profibrotic vascular intussusception and angiocrine factors to sustain lung regeneration | Science Translational Medicine
2024-08-29 Next-generation CAR T cell therapies for glioblastoma | Science Translational Medicine
2024-08-29 Erratum for the Research Article “MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells” by S. Perrin et al. | Science Translational Medicine
2024-08-22 Stress-induced eosinophil activation contributes to postoperative morbidity and mortality after lung resection | Science Translational Medicine
2024-08-22 Microglia-specific IL-10 gene delivery inhibits neuroinflammation and neurodegeneration in a mouse model of Parkinson’s disease | Science Translational Medicine
2024-08-22 Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2 in mice | Science Translational Medicine
2024-08-22 Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies | Science Translational Medicine
2024-08-22 Repeated Omicron exposures redirect SARS-CoV-2–specific memory B cell evolution toward the latest variants | Science Translational Medicine
2024-08-15 Acyl-CoA binding protein for the experimental treatment of anorexia | Science Translational Medicine
2024-08-15 Natural killer cells promote neutrophil extracellular traps and restrain macular degeneration in mice | Science Translational Medicine
2024-08-15 Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model | Science Translational Medicine
2024-08-15 Development and preclinical validation of 2-deoxy 2-[18F]fluorocellobiose as an Aspergillus-specific PET tracer | Science Translational Medicine
2024-08-15 Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier | Science Translational Medicine
2024-08-15 An identity crisis for lung cancer cells | Science Translational Medicine
2024-08-15 Erratum for the Research Article “A β-Arrestin–Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation” by D. Gesty-Palmer et al. | Science Translational Medicine
2024-08-08 Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity | Science Translational Medicine
2024-08-08 A self-amplifying RNA vaccine prevents enterovirus D68 infection and disease in preclinical models | Science Translational Medicine
2024-08-08 In vivo Bruton’s tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis | Science Translational Medicine
2024-08-08 Piplartine attenuates aminoglycoside-induced TRPV1 activity and protects from hearing loss in mice | Science Translational Medicine
2024-08-08 Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas–based epigenome editing in Alzheimer’s disease | Science Translational Medicine
2024-08-01 MGA deletion leads to Richter’s transformation by modulating mitochondrial OXPHOS | Science Translational Medicine
2024-08-01 Functional and epigenetic changes in monocytes from adults immunized with an AS01-adjuvanted vaccine | Science Translational Medicine
2024-08-01 A prM mutation that attenuates dengue virus replication in human cells enhances midgut infection in mosquitoes | Science Translational Medicine
2024-08-01 A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates | Science Translational Medicine
2024-08-01 Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients | Science Translational Medicine

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